phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway
| PAG Title | phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway |
| PAG ID | WAG001022 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Map kises transduce responses to extracellular sigls by a variety of routes, and communicate with other pathways through extensive crosstalk networks. A closely studied Map kise cascade origites with tyrosine kise activation, and activation of Ras. Ras activates Raf, Raf activates the Map kise kises Mek1 and Mek2 and these kises activate downstream Map kises like Erk1 and Erk2. Erk1 and Erk2 in turn activate transgenes like p35 through the Map kise activated transcription factor EGR-1. |
| Species | Homo sapiens |
| nCoCo Score | 2,405 |
| Base PAG ID | WAG001022 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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